Cellular and Molecular Immunology· 2026Q1· Derleme
Kronik inflamasyonun kritik orkestratörleri olarak nötrofiller
Neutrophils as critical orchestrators of chronic inflammation
- 57atıf
- Q1SCImago
- 2026yıl
Kısa özet
Akut patojen savunmasıyla bilinen nötrofiller, artık aşırı aktivasyon yoluyla kronik inflamasyona neden oldukları ve sürdürülebilir doku hasarına yol açtıkları anlaşılmaktadır.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Nötrofiller, hiperinflamatuar bir fenotip aracılığıyla kronik inflamasyona katkıda bulunur.
- Aşırı aktivasyon, kontrolsüz NET oluşumu, ROS üretimi ve medyatör salınımına yol açar.
- Nötrofiller, endotel hücreleri, monositler, trombositler ve lenfositlerle çapraz etkileşim yoluyla inflamasyonu ve doku yeniden şekillenmesini orkestre eder.
- Bu anlayış, kronik hastalıkta iç ve adaptif bağışıklık arasındaki katı ikiliği sorgulamaktadır.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Neutrophils are the first key effector innate immune cells recruited toward inflammatory sites. Through the release of neutrophilic extracellular traps (NETs), the production of reactive oxygen species (ROS), degranulation and phagocytosis, neutrophils play a central role in the rapid elimination of invading pathogens. Recently, increasing attention has been given to the role of neutrophils in chronic inflammation, challenging the dichotomy between innate and adaptive immune responses. In chronic inflammatory conditions, neutrophils generally display a hyperinflammatory phenotype via dysregulated pathogen defense mechanisms. Excessive neutrophil activation may result in aberrant cell death, uncontrolled oxidative burst or NET formation and sustained release of inflammatory mediators such as proteases and inflammatory cytokines. Therefore, neutrophils contribute to the development of a sustained inflammatory environment and cause collateral tissue damage. In addition to their direct inflammatory effects, neutrophils further orchestrate inflammation and tissue remodeling by actively engaging in crosstalk with other cells within the immune microenvironment, such as endothelial cells, monocytes, platelets, and T and B cells. This review summarizes the current knowledge of the emerging role of neutrophils in the context of chronic inflammation. The key characteristics of neutrophils and their interactions with distinct cell types are discussed within the initial part of the review, whereas the second part focuses on their contributions to the pathophysiology of immune-driven diseases, including rheumatoid arthritis, atherosclerosis, inflammatory bowel disease, systemic lupus erythematosus, chronic obstructive pulmonary disease, and fibrotic disorders. Increasing knowledge on neutrophil behavior in the context of chronic inflammation may offer novel insights into disease pathology and, potentially, the identification of novel therapeutic targets.
Yazarların özeti; kaynağından alınmıştır. Cellular and Molecular Immunology, 2026 · DOI ↗
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