Journal of Pharmaceutical Research International· 2021· Review
The Impact of Metformin in Pediatric Type-1 Diabetes Mellitus in Addition to Insulin Therapy; Literature Review
- 0citations
- 2021year
Short summary
Adding metformin to insulin therapy in pediatric Type-1 diabetes shows promise for cardiovascular protection, though its impact on glycemic control remains controversial.
AI-generated from the title and abstract; the full text is not read.
Key points
- Metformin may provide cardiovascular protection in pediatric Type-1 diabetes when added to insulin therapy.
- Intensified insulin therapy can increase insulin resistance and body weight, negatively impacting cardiovascular health.
- The effect of metformin on glycemic control in Type-1 diabetes is controversial.
- More multi-systemic randomized clinical trials are needed to confirm metformin's benefits and clarify its impact on glycemic control.
AI-generated from the title and abstract; the full text is not read.
Abstract
Background: Type 1 diabetes mellitus leads to significant cardiovascular risk through various mechanisms. Intensified insulin therapy is commonly required to achieve adequate glycemic control and reduce HbA1c. However, when insulin dose increases, it might increase insulin resistance and body weight, which directly affecting the cardiovascular profile. Objective: We aim in this literature review to address the role of adding metformin to insulin therapy to limit the cardiovascular effect, insulin resistance and improve glycemic control in pediatric age. Methods: We searched in the PubMed database for relevant articles using the following Mesh words: Metformin - Type 1 diabetes mellitus, pediatrics - Cardiovascular risk. Conclusion: Metformin was found to has promising cardiovascular protection when adding to insulin therapy. However, the impact of metformin in type 1 diabetes mellitus glycemic control is controversial, and further multi-systemic randomized clinical trials are recommended to address this issue.
The authors' abstract, as published at the source. Journal of Pharmaceutical Research International, 2021 · DOI ↗
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Field: Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and MetabolismMedicine