Immunity Inflammation and Disease· 2025Q2· Derleme
Periodontitisde Reaktif Oksijen Türlerinin (ROS) Rolü: Potansiyel Bir Terapötik Hedef
The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target
- 35atıf
- Q2SCImago
- 2025yıl
Kısa özet
Aşırı reaktif oksijen türleri (ROS), NF-κB ve MAPK gibi sinyal yollarını ve TXNIP ve MAVS gibi proteinleri aktive ederek periodontal doku yıkımını tetikler ve periodontitis için terapötik bir hedef sunar.
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Ana noktalar
- Aşırı ROS üretimi, inflamasyonu ve periodontal doku yıkımını şiddetlendirerek oksidatif strese neden olur.
- ROS, periodontitisde NF-κB ve MAPK gibi sinyal yollarını ve TXNIP ve MAVS gibi proteinleri aktive eder.
- Gelişmekte olan tedaviler arasında antioksidanlar, fotodinamik terapi (PDT) ve nanomateryaller bulunur.
- NLRP3 inflammasomunu antioksidan/ROS modüle edici tedavilerle hedeflemek umut verici bir stratejidir.
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Özet (abstract)
BACKGROUND: ROS are pivotal in maintaining periodontal tissue health due to their dual role in physiological and pathological states. At physiological levels, ROS are essential for host defense, effectively eliminating pathogenic bacteria during inflammation and sustaining the homeostasis of the periodontal microenvironment. However, excessive ROS production disrupts the balance between oxidative activity and antioxidant defenses, leading to oxidative stress (OS). This imbalance exacerbates inflammation, damages cellular components, and drives periodontal tissue destruction. Recognizing the dual role of ROS underscores the importance of studying their regulatory mechanisms, which is crucial for advancing understanding and therapeutic strategies in periodontitis management. OBJECTIVE: This review summarizes the latest research advancements on the molecular mechanisms linking ROS to the progression of periodontitis and explores related therapeutic strategies. RESULTS: This review focuses on the pivotal role and specific mechanisms of periodontal tissue destruction by excess ROS, which mediate signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK), as well as the activation of OS response-associated proteins, including thioredoxin-interacting protein (TXNIP) and mitochondrial antiviral signaling protein (MAVS). Additionally, we provide a concise summary of emerging therapeutic strategies for periodontitis, including the use of antioxidants, photodynamic therapy (PDT), and nanomaterials. Gaining a more profound comprehension of these mechanisms may pave the way for the formulation of enhanced therapeutic strategies for periodontitis. CONCLUSION: Understanding the interplay between ROS and periodontal tissue destruction is essential for advancing periodontitis research. Targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome with antioxidant and ROS-modulating therapies presents a promising strategy to mitigate both inflammation and OS, thereby reducing periodontal degradation.
Yazarların özeti; kaynağından alınmıştır. Immunity Inflammation and Disease, 2025 · DOI ↗
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Alan: Periodontoloji
PeriodonticsDentistry