BMC Oral Health· 2026Q1
STAT4, IL-10 ve HLA Gen Varyantları Dental Klinik Hastalarında Sjögren Hastalığı ile İlişkili
Single nucleotide polymorphisms in STAT4, IL-10, and HLA genes are associated with Sjögren’s disease in dental clinic patients: a case-control study and meta-analysis
- 0atıf
- Q1SCImago
- 2026yıl
Kısa özet
STAT4, IL-10 ve HLA genlerindeki belirli tek nükleotid polimorfizmleri (SNP'ler), vaka-kontrol çalışması ve meta-analize göre, diş hekimliği kliniklerinde başvuran hastalarda Sjögren hastalığı (SjD) ile anlamlı derecede ilişkilidir.
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Ana noktalar
- IL-10, STAT4 ve HLA genlerindeki belirli SNP'ler, diş hekimliği kliniklerinde Sjögren hastalığı (SjD) olan hastalarda anlamlı derecede ilişkilidir.
- STAT4 (rs7574865, rs7582694), resesif bir model altında ilişki gösterirken, IL-10 (rs1800896) ve HLA (rs6457374), kodominant bir model altında ilişkilendirildi.
- Meta-analiz, GTF2I, TNFAIP3 ve TNF dahil olmak üzere diğer ilişkili lokusları belirledi.
- Diş hekimliği kliniği SjD hastalarındaki genetik ilişkiler, özellikle IL-10 ve HLA için, bilinen SjD lokuslarına kıyasla belirgin farklılıklar gösterdi.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Sjögren’s disease (SjD) is clinically heterogeneous, and a subset of patients seen in dental clinics represents a clinically defined subgroup. Understanding their genetic profile and relationship to established SjD susceptibility loci may facilitate early risk stratification and inform precision diagnostic strategies. A case-control study was conducted including 123 SjD patients from Peking University School and Hospital of Stomatology, using 1000 Genomes Phase 3 CHB and CHS populations as controls. Thirty single nucleotide polymorphisms (SNPs) in candidate genes were genotyped using MALDI-TOF mass spectrometry. Logistic regression was applied to evaluate genetic associations with SjD susceptibility. A meta analysis was conducted to identify established SjD susceptibility loci, which were then compared with findings from dental clinic SjD patients. Dental clinic SjD patients exhibited distinct clinical features: 73.20% reported sicca symptoms, 55.3% had salivary gland swelling, and 64.2% showed imaging abnormalities of the salivary glands. Significant associations were observed for IL-10 rs1800896 T > C; STAT4 (rs7574865 T > G, rs7582694 C > G); HLA (rs115575857 A > G, rs6457374 C > T); TNF rs1799964 T > C; and BLK rs13277113 G > A under the codominant model. Logistic regression confirmed significant associations of HLA rs6457374 C > T and IL-10 rs1800896 T > C under the codominant model, whereas STAT4 (rs7574865 T > G, rs7582694 C > G) showed significant associations under the recessive model. Meta-analysis identified GTF2I rs117026326 C > T, STAT4 rs7582694 C > G, TNFAIP3 (rs2230926 T > G, rs5029939 C > G), and TNF rs1800629 G > A as significantly associated loci. STAT4 (rs7574865 T > G and rs7582694 C > G) and TNF rs1799964 T > C showed consistent or partially consistent association patterns, whereas IL-10 rs1800896 T > C and HLA (rs115575857A > G, rs6457374 C > T) showed distinct association patterns in dental clinic SjD patients. STAT4 , IL-10 , and HLA loci are significantly associated with SjD in dental clinic patients. HLA rs6457374 C > T was associated with dental clinic SjD in a Chinese population, providing new insights into the genetic basis of this clinically defined subgroup.
Yazarların özeti; kaynağından alınmıştır. BMC Oral Health, 2026 · DOI ↗
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