Ipomoea Aquatica Ekstraktlarının Sıçanlarda Streptozotosin-Diyabet Kaynaklı Karaciğer, Oksidatif Stres ve Kanser Hücre Hatlarındaki Değişiklikleri Azaltması

Özet (abstract)

Abstract This study aimed to investigate the potential ameliorative and antihyperglycemic effects of two fractions ofIpomoea aquaticaon liver functions in streptozotocin (STZ)-induced diabetic male rats. Eighteen adult male albino rats were divided into three groups: control,STZ + 200 mg/kgIA6-1(dichloromethane-ethyl acetate fraction), andSTZ + 200 mg/kgIA9-2(ethyl acetate-methanol fraction).In vitro, antiproliferative activity against liver cancer cell lines (HepG2) was examined. Additionally, the plasma protein profile ofSTZ-induced diabetic rats was investigated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Results showed a significant increase in serum alkaline phosphatase (ALP) and aspartate aminotransaminase (AST) in both treated groups compared to the control, whereas there was no significant difference between groups in the serum levels of alanine aminotransaminase (ALT), total protein, and albumin. Thein vivototal antioxidant capacity (TAC) showed a significant increase in both treated groups compared to the control, indicating thatI. aquaticamay enhance the antioxidant defense system of the liver, which could help protect the liver from oxidative stress-induced damage. The profile of C-reactive protein (C-RP) (28.3 kDa) and apelin (16 kDa) inSTZrats showed a higher intensity compared to the control group and both treated groups. These proteins may play a role in regulating inflammation and oxidative stress in the liver, which are important mechanisms in the pathogenesis of liver diseases. Moreover, theIA6-1fraction had a more potent antiproliferative effect on liver cancer HepG2cell lines compared to theIA9-2fraction. This suggests that the plant may have a protective effect against liver damage caused by cancer cells. Overall, these findings highlight the potential therapeutic applications ofI. aquaticafor the treatment of liver diseases, particularly those associated with oxidative stress and inflammation. However, further research is needed to fully elucidate the mechanisms underlying the plant's beneficial effects on liver function and to determine optimal dosages and treatment durations for humans. Additionally, clinical trials will be necessary to confirm the safety and efficacy ofI. aquaticaas a therapeutic agent for liver diseases in humans.

Yazarların özeti; kaynağından alınmıştır. BioChem, 2026 · DOI ↗