Contact Dermatitis· 2026Q1
Orta-Şiddetli Atopik Dermatitli Çocuklarda Bir Üçüncül Başvuru Kohortunda Temas Duyarlılığı ve Polisenzitizasyon
Contact Sensitization and Polysensitization in a Tertiary Referral Cohort of Children With Moderate‐To‐Severe Atopic Dermatitis
- 0atıf
- Q1SCImago
- 2026yıl
Kısa özet
Orta-şiddetli atopik dermatitli (AD) çocukların neredeyse tamamı (%90,7) bir üçüncül başvuru kohortunda temas duyarlılığı (CS) gösterdi ve yarısı (%50,0) polisenzitizeydi; en sık nikel sülfat, kobalt klorür, potasyum dikromat ve propolis alerjenlerine karşı.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Orta-şiddetli AD'li çocukların %90,7'sinde temas duyarlılığı (CS) tespit edildi.
- Bu çocukların %50,0'ı polisenzitizeydi (≥3 alerjen).
- Nikel sülfat (%31,5), kobalt klorür (%31,5), potasyum dikromat (%27,8) ve propolis (%24,1) en sık görülen alerjenlerdi.
- Polisenzitize hastalar arasında propolis ve kobalt en sık görülen eş duyarlılık örüntüsünü oluşturdu (%40,7).
- Temas duyarlılığı ve polisenzitizasyon, yaş, hastalık şiddeti veya topografik dağılımla anlamlı olarak ilişkili bulunmadı.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
ABSTRACT Background Children with atopic dermatitis (AD) demonstrate increased susceptibility to contact sensitization (CS) due to epidermal barrier dysfunction and chronic cutaneous inflammation. However, the frequency and patterns of contact sensitization in paediatric AD remain incompletely defined. Objectives To evaluate the frequency of CS in a selected tertiary referral cohort of children with AD, and to assess associations with age, disease severity, and topographic phenotypes. Materials and Methods In this cross‐sectional study, 54 children (≤ 18 years) with AD underwent standardized patch testing using a modified paediatric baseline series. Reactions graded +, ++, or +++ were considered positive, whereas doubtful and irritant reactions were excluded. Polysensitization was defined as positivity to ≥ 3 allergens. Associations between sensitization status, topographic distribution (head and neck, trunk, palmo‐plantar), and disease severity were analysed using Fisher's exact test and Mann–Whitney U test, as appropriate. Results CS was identified in 49/54 patients (90.7%), while polysensitization was observed in 27/54 children (50.0%). The most frequent allergens were nickel sulphate and cobalt chloride, each detected in 17 patients (31.5%), followed by potassium dichromate in 15 patients (27.8%) and propolis in 13 patients (24.1%). Among polysensitized patients, propolis sensitization was identified in 40.7%, with propolis and cobalt representing the most frequent co‐sensitization pattern. Exploratory analysis of the five most frequent allergens showed no statistically significant associations with topographic phenotypes. Furthermore, neither contact sensitization nor polysensitization burden demonstrated significant associations with age and disease severity. Conclusions Our findings support consideration of patch testing in children with moderate‐to‐severe AD, regardless of their age, disease severity, and topographic phenotype.
Yazarların özeti; kaynağından alınmıştır. Contact Dermatitis, 2026 · DOI ↗
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