Yasal erişim ile yasa dışı piyasa kenevirinin kullanıma ve ruh sağlığına etkileri: Rastgele kontrollü bir çalışma

Özet (abstract)

Abstract Aims We measured the effects of public health‐oriented cannabis access compared with the illegal market on cannabis use and related mental health outcomes in adult cannabis users. Design This was a two‐arm, parallel group, open‐label, randomized controlled trial. Follow‐up outcome measurement took place after 6 months. Setting The study was conducted in Basel‐Stadt, Switzerland. Participants A total of 378 adult (aged ≥18 years) cannabis users were enrolled and randomized between August 2022 and March 2023, although only 374 users who completed baseline measures could be included. Intervention and Comparator Participants were randomly assigned to the intervention group with public health‐oriented recreational cannabis access in pharmacies (regulated cannabis products, safer use information, voluntary counseling, no advertisement; 189/188) or the illegal market control group (continued illicit cannabis sourcing; 189/186). Measurements The primary outcome was self‐reported severity of cannabis misuse after 6 months, as measured by the Cannabis Use Disorders Identification Test – Revised (range 0–32). Secondary outcomes involved depressive, anxiety, and psychotic symptoms, cannabis consumption amount, alcohol, and drug use. Findings Ten participants were not followed (2.7%). Primary analysis included those with complete data (182 vs. 182). There was some evidence of a difference in cannabis misuse between the legal cannabis intervention group (mean [M] = 10.1) and the illegal market control group (M = 10.9; β = −0.69, 95% confidence interval [CI] = −1.4 to 0.0, P = 0.052). These results were supported by an intention‐to‐treat multiple imputation analysis (n = 374). Additional sub‐group analysis by whether the participant used other drugs or not suggested that any reduction in cannabis misuse was confined to those in the legal cannabis intervention group who used other drugs ( P Interaction < 0.001). We found no statistically significant changes in any of the secondary outcomes. Conclusions Public health‐oriented recreational cannabis access may decrease cannabis use and cannabis‐related harms, especially among those using other drugs.

Yazarların özeti; kaynağından alınmıştır. Addiction, 2025 · DOI ↗