Journal of Molecular Neuroscience· 2026Q2
ABCC9/SUR2'nin Gliovasküler Birim Hücrelerinde, Astrositler Dahil, Karmaşık Bir İfade Paterni Vardır
ABCC9/SUR2 has a Complex Expression Pattern in Human Brain Gliovascular Unit Cells, Including Astrocytes
- 0atıf
- Q2SCImago
- 2026yıl
Kısa özet
İnsan beynindeki astrositler, perisitler, düz kas hücreleri ve endotel hücreleri SUR2 transkriptlerini ifade eder; astrositlerde tiroid hormonu sinyalizasyonuna yönelik zenginleşme ve artmış SUR2 ifadesiyle ilişkili spesifik bir ABCC9 varyantı (rs1914361) gözlemlenmiştir.
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Ana noktalar
- SUR2 transkriptleri insan beynindeki perisitlerde, astrositlerde, düz kas hücrelerinde ve endotel hücrelerinde ifade edilir.
- SUR2 açısından zenginleşmiş bir insan astrosit alt kümesi, tiroid hormonu sinyalizasyonuna duyarlılık göstermektedir.
- ABCC9 varyantı rs1914361, astrositlerde artmış SUR2 ifadesiyle ilişkilidir.
- Astrositler, SUR2B mRNA ekson varyantını tercihli olarak ifade eder.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
The ABCC9 gene and its cognate protein SUR2 play important roles in neurovascular coupling and are implicated in hippocampal sclerosis of aging (HS-Aging). However, prior studies have not focused on human brain SUR2 expression or SUR2 in glial cells. Here we analyzed cell type-specific ABCC9 /SUR2 expression patterns, and correlation with known genetic risk variants, using multiple data sets and a novel antiserum. Existing single-nucleus RNA sequencing data sets and new spatial transcriptomics data indicated that SUR2 transcripts were expressed primarily in human brain pericytes, astrocytes, smooth muscle cells, and endothelial cells. Evaluation of Sur2 expression in a sample of mice brains showed similar results except Sur2 was not detected in the mice astrocytes. In a SUR2 -enriched subcluster of human astrocytes, the pattern of transcript expression suggested responsiveness to thyroid hormone signaling: SUR2 -correlated gene products were enriched for thyroid hormone-sensitive transcripts and SLCO1C1 , the astrocyte thyroid hormone importer, was the transcript with the strongest correlation with SUR2 expression. Cells in the SUR2 + astrocyte cluster tended to have been derived from individuals lacking severe Alzheimer’s disease pathology. An ABCC9 single nucleotide variant (rs1914361, also a HS-Aging risk allele) was associated with increased SUR2 expression in astrocytes, but not other cell types. SUR2 mRNA splicing differed between cell types; astrocytes preferentially expressed the SUR2B variant. A novel SUR2 antiserum immunolabeled blood vessel walls and some astrocyte-morphology cells in human brain. Overall, human brain SUR2 expression was enriched among different cell types of the gliovascular unit. A SUR2 -enriched, possibly-homeostatic astrocyte subcluster suggested connections to thyroid hormone signaling.
Yazarların özeti; kaynağından alınmıştır. Journal of Molecular Neuroscience, 2026 · DOI ↗
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