Journal of Clinical Investigation· 2020Q1
Koronavirüs Hastalığı 2019 (COVID-19) Şiddetli ve Orta Dereceli Vakalarının Klinik ve İmmünolojik Özellikleri
Clinical and immunological features of severe and moderate coronavirus disease 2019
- 5.080atıf
- Q1SCImago
- 2020yıl
Kısa özet
Şiddetli COVID-19 vakalarında (n=11), orta dereceli vakalara (n=10) kıyasla T lenfositlerinin (294.0'a karşılık 640.5 x 10^6/L), CD4+ T hücrelerinin (177.5'e karşılık 381.5 x 10^6/L) ve CD8+ T hücrelerinin mutlak sayılarında belirgin derecede düşüş gözlemlenmiştir.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Şiddetli COVID-19 hastalarında, orta dereceli vakalara göre T lenfositleri, CD4+ T hücreleri ve CD8+ T hücrelerinin mutlak sayıları anlamlı derecede düşüktü.
- Şiddetli vakalarda IL-2R, IL-6, IL-10 ve TNF-α dahil olmak üzere inflamatuar sitokin seviyeleri belirgin şekilde yüksekti.
- Şiddetli vakalarda CD4+ T hücrelerinden IFN-γ ifadesi, orta dereceli vakalara (%22.8) göre daha düşüktü (%14.1).
- Ateş, öksürük ve yorgunluk yaygın klinik belirtilerdi; şiddetli vakalar dispne, lenfopeni ve hipoalbüminemiye daha yatkındı.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
BACKGROUNDSince December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODSIn this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTSThe median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSIONThe SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATIONThis is a retrospective observational study without a trial registration number.FUNDINGThis work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).
Yazarların özeti; kaynağından alınmıştır. Journal of Clinical Investigation, 2020 · DOI ↗
Ücretsiz hesapla devam et
Makaleye Sor ile bu makaleye günde 3 soru ücretsiz; makaleyi kaydet, kaynakçasını al, ilgi alanına göre her gün yeni özetler. Çıkarımlar Premium.
Web'de ücretsiz devam etGoogle ya da Apple hesabınla giriş; kart istemez. Bu makaleye geri dönersin.
Telefonda:
Alan: Enfeksiyon Hastalıkları
Infectious DiseasesMedicine