Kısa süreli ağırlıksızlık dönemleri, internal karotis arter boyunca tahmini internal karotis arter akış hacmini değiştirmez

Özet (abstract)

Abstract A number of studies have well described central cardiovascular changes caused by changing gravity levels as they occur e.g. during parabolic flight. However limited data exists describing the effect of microgravity on the cerebrovascular system and brain perfusion, which might heavily affect the intracranial pressure (ICP). In this study, performed on board the Airbus A310 ZeroG, the internal carotid artery (ICA) was examined for five consecutive parabolas during predefined windows at the start and end of each gravity phase (1G, 1.8G/pull-up, 0G, 1.8G/pull-out) by cardiac-gated B mode ultrasonography using a 7–12 MHz linear transducer. ICA diameter and Doppler-derived velocity were recorded during predefined windows, and estimated ICA flow volume was derived offline. Simultaneously heart rate (HR) was monitored. Data was assessed in the 1G condition pre parabola and at the start and end of each 1.8G and 0G phase. A lab-based study was administered where participants repeatedly changed between a seated and six-degree head down tilt (HDT) position for 20 s. During parabolic flight, HR increased during the two hypergravity phases and decreased back to 1G baseline in the weightlessness phase of the parabola. Blood flow velocity and flow volume showed a clear decrease in the first 1.8 hypergravity phase but returned to 1G baseline in the microgravity phase. Different results were obtained by changing from a seated to a 6°HDT position, resulting in an increase in ICA diameter, flow velocity and flow volume. The present findings do not support a significant increase in extracranial ICA inflow during short periods of weightlessness, and that MCA velocity changes may not necessarily indicate increased cerebral blood flow volume.

Yazarların özeti; kaynağından alınmıştır. Scientific Reports, 2026 · DOI ↗