BD-II Hastalarında BD-I'ye Göre Daha Düşük Direnç ve Yaşam Kalitesi Gözlendi

Özet (abstract)

Abstract Background Individuals with bipolar disorder (BD) exhibit lower psychological resilience and quality of life (QoL) than healthy individuals, but whether these outcomes differ between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) remains unclear. This study compared psychological resilience and QoL among euthymic individuals with BD-I and BD-II and healthy controls. It also examined the associations between resilience and QoL. Methods The study included 51 euthymic patients with BD (BD-I n = 27; BD-II n = 24) and 43 healthy controls comparable in age, sex, and education. Psychological resilience was assessed using the Resilience Scale for Adults (RSA), QoL using the World Health Organization Quality of Life-BREF (WHOQOL-BREF), residual depressive symptoms using the Hamilton Depression Rating Scale (HAM-D), and perceived stress using the Perceived Stress Scale (PSS). Group comparisons, multiple regression, and hierarchical regression were performed. Benjamini–Hochberg corrections and influential-observation sensitivity analyses were used to assess the robustness of the findings. Results RSA scores were lower in the BD-II group than in the BD-I and healthy control groups ( p = 0.002). Participants with BD-II also had higher residual depressive symptoms and perceived stress scores, more lifetime depressive episodes, and poorer QoL across several domains. In the patient-level regression model, the association between BD-II diagnosis and lower resilience was attenuated and was no longer statistically significant after adjustment for number of depressive episodes and residual depressive symptoms. In the BD-II subgroup, resilience was positively associated with psychological QoL after adjustment for age, perceived stress, and residual depressive symptoms (β = 0.656, p < 0.001), and this association remained significant after correction for multiple testing. Conclusions Individuals with BD-II exhibited lower psychological resilience and poorer QoL in several domains compared with those with BD-I and healthy controls. The association between BD-II diagnosis and lower resilience was attenuated after adjustment for depressive episode burden and residual depressive symptoms; however, their relative contributions cannot be determined given the cross-sectional design and their clinical interrelationship. Psychological resilience remained associated with psychological QoL in BD-II after covariate adjustment. Psychological resilience may warrant further investigation as a potential therapeutic target in longitudinal and interventional studies.

Yazarların özeti; kaynağından alınmıştır. International Journal of Bipolar Disorders, 2026 · DOI ↗