Signal Transduction and Targeted Therapy· 2023Q1
Nörodejeneratif hastalıklarda mikroglia: mekanizma ve potansiyel terapötik hedefler
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
- 1.436atıf
- Q1SCImago
- 2023yıl
Kısa özet
Reaktif mikroglialar, bazı durumların hastalık belirtileri ve belirli işlevlerle ilişkili olduğu uzaysal ve zamansal heterojenlik gösterir; hem koruyucu (fagositoz) hem de zararlı (nöroinflamasyon) olabilirler.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Mikroglia aktivasyonu, nörodejeneratif hastalıkların bir özelliğidir ve karmaşık uzaysal ve zamansal heterojenlik sergiler.
- Reaktif mikroglialar hem koruyucu (agregatları temizleme) hem de zararlı (inflamasyon ve bozulmuş fagositoz) olabilir.
- Periferik bağışıklık hücrelerinin sızması ve mikroglial eksozom vezikülleri hastalık ilerlemesine katkıda bulunur.
- Terapötik stratejiler, mikroglial fagositozu artırmaya, nöroinflamasyonu azaltmaya ve koruyucu fenotipleri teşvik etmeye odaklanır.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. Some identified microglia in specific states correlate with pathological hallmarks and are associated with specific functions. Microglia both exert protective function by phagocytosing and clearing pathological protein aggregates and play detrimental roles due to excessive uptake of protein aggregates, which would lead to microglial phagocytic ability impairment, neuroinflammation, and eventually neurodegeneration. In addition, peripheral immune cells infiltration shapes microglia into a pro-inflammatory phenotype and accelerates disease progression. Microglia also act as a mobile vehicle to propagate protein aggregates. Extracellular vesicles released from microglia and autophagy impairment in microglia all contribute to pathological progression and neurodegeneration. Thus, enhancing microglial phagocytosis, reducing microglial-mediated neuroinflammation, inhibiting microglial exosome synthesis and secretion, and promoting microglial conversion into a protective phenotype are considered to be promising strategies for the therapy of neurodegenerative diseases. Here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies and Huntington's disease. We also summarize the possible microglia-targeted interventions and treatments against neurodegenerative diseases with preclinical and clinical evidence in cell experiments, animal studies, and clinical trials.
Yazarların özeti; kaynağından alınmıştır. Signal Transduction and Targeted Therapy, 2023 · DOI ↗
Ücretsiz hesapla devam et
Makaleye Sor ile bu makaleye günde 3 soru ücretsiz; makaleyi kaydet, kaynakçasını al, ilgi alanına göre her gün yeni özetler. Çıkarımlar Premium.
Web'de ücretsiz devam etGoogle ya da Apple hesabınla giriş; kart istemez. Bu makaleye geri dönersin.
Telefonda:
Alan: Nöroloji (Sinirbilim)
NeurologyNeuroscience