npj Biofilms and Microbiomes· 2025Q1· Review
Fusobacterium in the microbiome: from health to disease across the oral–gut axis and beyond
- 38citations
- Q1SCImago
- 2025year
Short summary
Fusobacterium species are key players in the oral-gut axis, acting as both beneficial commensals and harmful pathogens that contribute to diseases like cancer by promoting inflammation and immune evasion.
AI-generated from the title and abstract; the full text is not read.
Key points
- Fusobacterium species are central to the oral-gut axis, influencing both oral and systemic health.
- These bacteria can act as both commensals and pathogens, contributing to disease development.
- Mechanisms include modulating microbial balance, promoting dysbiosis, and driving inflammation.
- Fusobacterium's roles in carcinogenesis involve promoting proliferation, invasion, and immune evasion.
AI-generated from the title and abstract; the full text is not read.
Abstract
Fusobacterium functions as both commensal and pathogen, linking the oral-gut axis to diverse diseases, including cancer. Evidence shows it modulates microbial balance, promotes dysbiosis, and contributes to carcinogenesis by driving inflammation, proliferation, invasion, and immune evasion. This review integrates ecological, molecular, and clinical insights, highlighting its roles in oral and systemic disease and discussing therapeutic potential, underscoring Fusobacterium's dualistic nature and implications for microbiome-targeted interventions.
The authors' abstract, as published at the source. npj Biofilms and Microbiomes, 2025 · DOI ↗
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Field: Periodontics
PeriodonticsDentistry