Oral Bakterileri, Bağırsak Mikrobiyomundan Daha Fazla Etkiyle HIV'de Sistemik Enflamasyonu Tetikliyor

Özet (abstract)

ABSTRACT Background Chronic HIV-1 infection is associated with increased inflammation-related comorbidities, despite effective viral suppression with antiretroviral therapy. While the role of the gut microbiome in inflammation is well-studied, the contribution of the oral microbiome remains less clear. This study investigates the relationship between the oral and gut microbiomes in driving systemic inflammation in persons with HIV. Methods This cross-sectional study utilized archived samples from 198 participants (99 with HIV and 99 without HIV). Oral microbiome composition was analyzed via 16S rRNA sequencing and systemic inflammatory biomarkers were measured using multiplex assays. Gut microbiome data from previous studies were integrated for comparative analyses. Bacterial inflammatory potential was assessed through in vitro co-culture and epithelial barrier permeability assays. Results The oral microbiome in HIV was characterized by increased Veillonella, Capnocytophaga , and Megasphaera , and several decreased genera including Fusobacterium . Using PERMANOVA, we found that the oral microbiome was a significant driver of cytokine variation in HIV compared to the gut microbiome, and identified specific associations with oral Veillonella and Megasphaera . We found no differences in anti- Veillonella parvula serum IgG by HIV status, but IgG titers did correlate with microbial translocation markers sCD14 and LBP in HIV. In vitro studies demonstrated that Veillonella parvula increased oral epithelial barrier permeability and induced monocyte activation. Conclusions The oral microbiome, particularly Veillonella parvula , may contributes to systemic inflammation in HIV through mechanisms involving epithelial barrier disruption, oral translocation, and monocyte activation.

Yazarların özeti; kaynağından alınmıştır. mSphere, 2026 · DOI ↗