Psychology and Aging· 2015Q1
A culture–brain link: Negative age stereotypes predict Alzheimer’s disease biomarkers.
- 190citations
- Q1SCImago
- 2015year
Short summary
Holding more-negative age stereotypes earlier in life predicts steeper hippocampal volume loss and greater accumulation of neurofibrillary tangles and amyloid plaques, biomarkers of Alzheimer's disease.
AI-generated from the title and abstract; the full text is not read.
Key points
- Negative age stereotypes predict Alzheimer's biomarkers, including hippocampal volume loss.
- Individuals with more-negative stereotypes showed greater accumulation of neurofibrillary tangles and amyloid plaques.
- Stereotype assessment occurred decades before brain imaging and autopsy.
- Findings adjusted for relevant covariates.
AI-generated from the title and abstract; the full text is not read.
Abstract
Although negative age stereotypes have been found to predict adverse outcomes among older individuals, it was unknown whether the influence of stereotypes extends to brain changes associated with Alzheimer's disease. To consider this possibility, we drew on dementia-free participants, in the Baltimore Longitudinal Study of Aging, whose age stereotypes were assessed decades before yearly magnetic resonance images and brain autopsies were performed. Those holding more-negative age stereotypes earlier in life had significantly steeper hippocampal-volume loss and significantly greater accumulation of neurofibrillary tangles and amyloid plaques, adjusting for relevant covariates. These findings suggest a new pathway to identifying mechanisms and potential interventions related to the pathology of Alzheimer's disease.
The authors' abstract, as published at the source. Psychology and Aging, 2015 · DOI ↗
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Field: Neuropsychology and Physiological Psychology
Neuropsychology and Physiological PsychologyPsychology