Life· 2025Q1
A One-Health Perspective of Antimicrobial Resistance (AMR): Human, Animals and Environmental Health
- 102citations
- Q1SCImago
- 2025year
Short summary
Antimicrobial resistance (AMR) is a global health crisis driven by widespread antibiotic use in agriculture and healthcare, leading to reduced treatment efficacy across humans, animals, and the environment.
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Key points
- AMR is a top global health threat, driven by inappropriate antibiotic use in agriculture and healthcare.
- Resistant bacteria spread horizontally, impacting human, animal, and environmental health.
- A One-Health perspective integrates human, animal, and environmental factors to combat AMR.
- Scientific advances include metagenomic sequencing, advanced wastewater treatment, and antibiotic alternatives.
- Global policy efforts and international collaboration are essential for sustainable AMR interventions.
AI-generated from the title and abstract; the full text is not read.
Abstract
Antibiotics are essential for treating bacterial and fungal infections in plants, animals, and humans. Their widespread use in agriculture and the food industry has significantly enhanced animal health and productivity. However, extensive and often inappropriate antibiotic use has driven the emergence and spread of antimicrobial resistance (AMR), a global health crisis marked by the reduced efficacy of antimicrobial treatments. Recognized by the World Health Organization (WHO) as one of the top ten global public health threats, AMR arises when certain bacteria harbor antimicrobial resistance genes (ARGs) that confer resistance that can be horizontally transferred to other bacteria, accelerating resistance spread in the environment. AMR poses a significant global health challenge, affecting humans, animals, and the environment alike. A One-Health perspective highlights the interconnected nature of these domains, emphasizing that resistant microorganisms spread across healthcare, agriculture, and the environment. Recent scientific advances such as metagenomic sequencing for resistance surveillance, innovative wastewater treatment technologies (e.g., ozonation, UV, membrane filtration), and the development of vaccines and probiotics as alternatives to antibiotics in livestock are helping to mitigate resistance. At the policy level, global initiatives including the WHO Global Action Plan on AMR, coordinated efforts by (Food and Agriculture Organization) FAO and World Organisation for Animal Health (WOAH), and recommendations from the O'Neill Report underscore the urgent need for international collaboration and sustainable interventions. By integrating these scientific and policy responses within the One-Health framework, stakeholders can improve antibiotic stewardship, reduce environmental contamination, and safeguard effective treatments for the future.
The authors' abstract, as published at the source. Life, 2025 · DOI ↗
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Applied Microbiology and BiotechnologyImmunology and Microbiology