Journal of Occupational and Environmental Medicine· 2026Q2
Occupational Cluster of Methylene Chloride Poisoning: A Case Series
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- Q2SCImago
- 2026year
Short summary
Eight workers exposed to methylene chloride fumes after a 200-liter leak in a pharmaceutical facility experienced mild-to-moderate symptoms, with all recovering fully after prompt supportive care.
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Key points
- Eight workers were exposed to methylene chloride fumes from a 200-liter leak in a pharmaceutical facility.
- Symptoms ranged from asymptomatic biochemical derangements to headache, nausea, and drowsiness.
- Management included workplace extraction, high-flow oxygen therapy, and serial monitoring.
- All workers recovered fully without neurological or cardiac sequelae at one-month follow-up.
AI-generated from the title and abstract; the full text is not read.
Abstract
We describe an occupational cluster of eight workers exposed to methylene chloride fumes following an accidental 200-liter leak of the chemical in a pharmaceutical facility in North India. All patients presented with a mild-to-moderate clinical spectrum, ranging from asymptomatic biochemical derangements to headache, nausea, and drowsiness. Management consisted of prompt workplace extraction, high-flow normobaric oxygen therapy via non-rebreather mask, and serial clinical and biochemical monitoring. All workers made a complete, uneventful recovery without neurological or cardiac sequelae at a one-month follow-up. This report highlights the clinical characteristics of acute methylene chloride toxicity, describes the clinical course and favourable outcomes associated with early supportive care, and reinforces the critical need for stringent industrial safety measures.
The authors' abstract, as published at the source. Journal of Occupational and Environmental Medicine, 2026 · DOI ↗
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Field: Emergency Medicine
Emergency MedicineMedicine