Science· 2016Q1
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
- 501citations
- Q1SCImago
- 2016year
Short summary
A new method identified 1.34 gigabases of Neandertal and 303 megabases of Denisovan DNA in 1523 individuals, including 35 previously unknown Melanesian genomes, revealing multiple Neandertal admixtures and signatures of adaptive introgression.
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Key points
- A new method was developed to identify DNA inherited from multiple archaic hominin ancestors.
- The method was applied to 1523 whole-genome sequences, including 35 new Island Melanesian genomes.
- 1.34 gigabases of Neandertal and 303 megabases of Denisovan DNA were recovered.
- Multiple instances of Neandertal admixture in non-African populations were identified.
- Genomic regions depleted of archaic sequences and signatures of adaptive introgression were characterized.
AI-generated from the title and abstract; the full text is not read.
Abstract
Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 previously unknown Island Melanesian genomes. In aggregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respectively. We use these maps of archaic sequences to show that Neandertal admixture occurred multiple times in different non-African populations, characterize genomic regions that are significantly depleted of archaic sequences, and identify signatures of adaptive introgression.
The authors' abstract, as published at the source. Science, 2016 · DOI ↗
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Field: Geography, Planning and Development
Geography, Planning and DevelopmentSocial Sciences