Nature Communications· 2019Q1
BMP9 stimulates joint regeneration at digit amputation wounds in mice
- 76citations
- Q1SCImago
- 2019year
Short summary
BMP9 treatment of digit amputation wounds in mice stimulates the regeneration of a complete synovial joint, including articular cartilage and a synovial cavity, which articulates with the stump bone.
AI-generated from the title and abstract; the full text is not read.
Key points
- BMP9 treatment of digit amputation wounds in mice regenerates a synovial joint.
- The regenerated joint includes articular cartilage and a synovial cavity.
- The Prg4 gene is required for this regeneration response.
- Sequential BMP2 and BMP9 treatment regenerates both bone and joint.
AI-generated from the title and abstract; the full text is not read.
Abstract
A major goal of regenerative medicine is to stimulate tissue regeneration after traumatic injury. We previously discovered that treating digit amputation wounds with BMP2 in neonatal mice stimulates endochondral ossification to regenerate the stump bone. Here we show that treating the amputation wound with BMP9 stimulates regeneration of a synovial joint that forms an articulation with the stump bone. Regenerated structures include a skeletal element lined with articular cartilage and a synovial cavity, and we demonstrate that this response requires the Prg4 gene. Combining BMP2 and BMP9 treatments in sequence stimulates the regeneration of bone and joint. These studies provide evidence that treatment of growth factors can be used to engineer a regeneration response from a non-regenerating amputation wound.
The authors' abstract, as published at the source. Nature Communications, 2019 · DOI ↗
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Field: Rheumatology
RheumatologyMedicine