International Journal of Molecular Sciences· 2026Q1
Lifespan Extension and Increased Resistance to Environmental Stressors Induced by 5-Hydroxy-4-phenylfuran-2(5H)-one in Caenorhabditis elegans
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- Q1SCImago
- 2026year
Short summary
A compound from aromatic vinegar, 5-hydroxy-4-phenylfuran-2(5H)-one (FG1), extended mean and maximum lifespan by up to 20% in C. elegans worms and enhanced resistance to heat and oxidative stress.
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Key points
- FG1 treatment extended mean and maximum lifespan in C. elegans.
- FG1 preserved locomotor activity in aging worms.
- Transcriptomic analysis showed FG1 upregulated detoxification and antioxidant genes.
- FG1 reduced lipofuscin and hydrogen peroxide accumulation.
- FG1 enhanced resistance to heat and paraquat-induced oxidative stress.
AI-generated from the title and abstract; the full text is not read.
Abstract
This study investigated whether 5-hydroxy-4-phenylfuran-2(5H)-one (FG1), a bioactive compound derived from aromatic vinegar, exerts anti-ageing effects in the nematode Caenorhabditis elegans. FG1 treatment significantly extended both mean and maximum lifespan and preserved locomotor activity during ageing. Transcriptomic analysis revealed that FG1 upregulated genes associated with detoxification, glutathione metabolism, oxidative phosphorylation, and longevity-regulating pathways. Gene ontology and pathway analyses suggested activation of antioxidant and xenobiotic defence systems. FG1 significantly extended lifespan in wild-type worms, whereas no statistically significant lifespan extension was detected in SKN-1-deficient worms, suggesting a possible involvement of SKN-1 signalling in the lifespan-extending effect of FG1. FG1 also reduced lipofuscin and hydrogen peroxide accumulation in vivo and enhanced resistance to heat- and paraquat-induced oxidative stress. Overall, these findings suggest that the effects of FG1 on longevity and stress resistance are associated with changes in antioxidant and detoxification responses, although the contribution of SKN-1 requires further investigation.
The authors' abstract, as published at the source. International Journal of Molecular Sciences, 2026 · DOI ↗
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AgingBiochemistry, Genetics and Molecular Biology