Analytical Chemistry· 2026Q1
How Can We Reliably Highlight Nanoscale Lipid Heterogeneities in Erythrocyte Membranes?
- 0citations
- Q1SCImago
- 2026year
Short summary
Atomic force microscopy-infrared spectroscopy (AFM-IR) reliably maps nanoscale lipid and protein heterogeneities in Gaucher disease (GD) red blood cells (RBCs), revealing disease-specific biochemical alterations.
AI-generated from the title and abstract; the full text is not read.
Key points
- AFM-IR provides nanoscale resolution for probing lipid distribution in red blood cells, surpassing conventional spectroscopy.
- An optimized workflow ensures the chemical and morphological stability of red blood cell samples for AFM-IR analysis.
- Gaucher disease (GD) red blood cells exhibit disease-specific biochemical alterations compared to healthy cells.
- Nanoscale heterogeneity in lipid and/or protein distributions was identified in GD red blood cells.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract This study explores atomic force microscopy-infrared spectroscopy (AFM-IR) to characterize red blood cells (RBC) affected by Gaucher disease (GD). Conventional mass spectrometry and vibrational spectroscopy lack the spatial resolution to probe lipid distribution at the nanoscale, justifying the use of AFM-IR. An optimized analytical workflow was developed, ensuring the chemical and morphological stability of RBC samples. Comparative analyses between healthy (CTL) and GD RBCs reveal disease-specific biochemical alterations, notably nanoscale heterogeneity in lipid and/or protein distributions. These findings establish AFM-IR as a powerful tool for high-resolution molecular mapping of pathological erythrocytes.
The authors' abstract, as published at the source. Analytical Chemistry, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
BiophysicsBiochemistry, Genetics and Molecular Biology