Journal of Cutaneous Pathology· 2026Q2
A Case of Alopecia Secondary to Dupilumab in a Patient With Atopic Dermatitis
- 0citations
- Q2SCImago
- 2026year
Short summary
A patient developed alopecia secondary to dupilumab treatment for atopic dermatitis, with histological findings distinct from common alopecia types, suggesting a Th2 pathway inhibition leading to sebaceous gland atrophy.
AI-generated from the title and abstract; the full text is not read.
Key points
- Dupilumab, used for atopic dermatitis, can rarely cause alopecia.
- Histological findings in this case were distinct from alopecia areata, telogen effluvium, or psoriatic alopecia.
- The proposed mechanism involves Th2 pathway inhibition leading to Th1 enhancement and sebaceous gland atrophy.
- This case contrasts with literature suggesting dupilumab might promote hair growth, highlighting potential negative effects on the pilosebaceous unit.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Dupilumab inhibits the signaling pathway of interleukins 4 and 13, and can be effective in the management of treatment‐refractory atopic dermatitis, with alopecia areata being uncommonly reported as a side effect and only limited to several cases. This is the case of a patient who experienced dupilumab‐induced alopecia in treatment for atopic dermatitis and whose histological exam represented findings distinct from classical alopecia areata, telogen effluvium, or underlying psoriatic alopecia, with a potential explanation being inhibition of the Th2 pathway, enhancing a Th1‐mediating response by the immune system leading to marked atrophy of the sebaceous glands, which is not reported in alopecia areata. While there is literature describing the potential growth effect of dupilumab in patients with alopecia, there are select reports, along with our case, that suggest its negative effects on the pilosebaceous unit and overall hair growth.
The authors' abstract, as published at the source. Journal of Cutaneous Pathology, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Urology
UrologyMedicine