Current Transplantation Reports· 2026Q2· Review
From Spectra to Clinical Insight: Raman Spectroscopy in Kidney Transplant Monitoring and Donor Assessment
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- Q2SCImago
- 2026year
Short summary
Raman spectroscopy and SERS can non-invasively assess kidney transplant health by detecting biochemical changes in molecular fingerprints, distinguishing transplant states, predicting outcomes, and differentiating T lymphocytes.
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Key points
- Raman spectroscopy and SERS provide non-invasive molecular fingerprints of kidney transplant health.
- SERS can distinguish between different transplant states using biofluids.
- Raman analysis of donor samples may predict transplant outcomes and identify viable organs.
- The techniques can differentiate between activated and non-activated T lymphocytes.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Purpose of Review Raman spectroscopy and surface-enhanced Raman scattering (SERS) are analytical techniques for non-invasive assessment of kidney transplant health. By producing molecular fingerprints through inelastic light scattering, they’re able to detect biochemical changes associated with graft injury, immune activation, and other relevant pathophysiological changes. This review synthesizes current evidence of Raman-based techniques across three key domains in kidney transplantation: transplant monitoring, donor organ assessment, and evaluation of alloreactive immune activation. Recent Findings Recent studies demonstrate that SERS can be applied to biofluids and can accurately distinguish between transplant states. Additionally, Raman-based analyses of donor-derived samples show potential for predicting transplant outcomes and identifying viable organs despite high-risk features. It has also been shown to differentiate between activated and non-activated T lymphocytes. Summary Raman spectroscopy and SERS represent powerful, non-invasive approaches that have the potential to reduce the reliance on invasive biopsy.
The authors' abstract, as published at the source. Current Transplantation Reports, 2026 · DOI ↗
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BiophysicsBiochemistry, Genetics and Molecular Biology