Science· 2026Q1
Wireless electrocatalytic closed-loop system for drug-free management of diabesity
- 1citations
- Q1SCImago
- 2026year
Short summary
A wirelessly powered implantable device (ECHO) uses electrocatalysis to convert blood glucose to gluconate, restoring glucose homeostasis and reducing weight in diabetic mice within 1 hour without hypoglycemia.
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Key points
- Developed an implantable, wirelessly powered electrocatalytic device (ECHO) for diabesity management.
- Device uses platinum-decorated gold nanoclusters to oxidize glucose to gluconate.
- In diabetic mice, ECHO restored glucose homeostasis within 1 hour, reduced body weight, and shifted metabolism without hypoglycemia.
- Autonomous, smartphone-controlled, drug-free closed-loop management of experimental diabesity was achieved.
AI-generated from the title and abstract; the full text is not read.
Abstract
Lifestyle-related type 2 diabetes and associated obesity (diabesity) affect >2.5 billion people worldwide and impose nearly $3 trillion in annual health care costs. We developed an implantable, wirelessly powered electrocatalytic closed-loop health optimization (ECHO) device containing platinum-decorated gold nanoclusters embedded in graphite felt that enabled selective, electrically tunable oxidation of blood glucose to renally cleared gluconate. In type 2 diabetic mice, wireless, low-power activation (0.75 volts, 10 milliamperes) restored glucose homeostasis within 1 hour, shifted metabolism from glucose to lipid utilization, reduced body weight and triglycerides, and increased circulating free fatty acids and ketone bodies without detectable hypoglycemia or adverse physiological, inflammatory, or behavioral effects during 6 weeks of treatment. Coupling this ECHO device to a commercial continuous glucose monitoring system enabled autonomous, smartphone-controlled, drug-free closed-loop management of experimental diabesity.
The authors' abstract, as published at the source. Science, 2026 · DOI ↗
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Field: Electrical and Electronic Engineering
Electrical and Electronic EngineeringEngineering