Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin· 2026Q1· Review
Intrahepatic cholangiocarcinoma: contemporary classification, molecular pathology, and emerging concepts
- 0citations
- Q1SCImago
- 2026year
Short summary
The 2026 WHO classification distinguishes small-duct and large-duct intrahepatic cholangiocarcinoma (iCCA), revealing distinct morphologic patterns, molecular alterations, and clinical outcomes.
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Key points
- The 2026 WHO classification distinguishes iCCA into small-duct and large-duct types.
- These subtypes show distinct morphologic patterns, immunohistochemical profiles, and molecular alterations.
- The classification impacts clinical outcomes and prognostication.
- Immunohistochemical and molecular biomarkers are essential for accurate diagnosis and targeted therapies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver malignancy with poor outcome. It is characterized by heterogeneous clinicopathological features as well as molecular landscapes. The updated World Health Organization (WHO) classification system underscores the critical distinction between small-duct and large-duct types, which exhibit distinct morphologic patterns, immunohistochemical profiles, molecular alterations, and clinical outcomes. Besides, rare and unique morphologic subtypes of iCCA continue to challenge diagnostic and treatment paradigms. This review provides an overview of the 2026 WHO classification and evolving concepts in iCCA, with a particular emphasis on the practical application of immunohistochemical and emerging molecular biomarkers essential for an accurate diagnosis and guiding targeted therapies. Furthermore, this manuscript addresses contemporary controversies and unresolved emerging practical issues with iCCA that are reshaping personalized therapeutic strategies and prognostication.
The authors' abstract, as published at the source. Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin, 2026 · DOI ↗
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Field: Surgery
SurgeryMedicine