PLoS ONE· 2026Q1
Tension reduction from inter-membrane counter-deformation accelerates nuclear electroporation
- 0citations
- Q1SCImago
- 2026year
Short summary
Inter-membrane counter-deformation under Coulomb force reduces membrane tension and accelerates electroporation of double membranes (like the nuclear envelope) compared to single membranes under nanosecond pulsed electric fields (nsPEFs).
AI-generated from the title and abstract; the full text is not read.
Key points
- Double membranes electroporate faster than single membranes under nsPEFs.
- Inter-membrane counter-deformation, driven by Coulomb force, reduces membrane tension.
- Reduced membrane tension and modulated electric fields accelerate electroporation.
- Double membranes may be more susceptible to nsPEF-induced cellular damage.
AI-generated from the title and abstract; the full text is not read.
Abstract
Pulsed electric field ablation is an emerging non-thermal modality for tumor treatment, in which electroporation of both the plasma membrane and the nuclear envelope plays a critical role in inducing irreversible cellular damage. To elucidate the different effects of nanosecond pulsed electric fields (nsPEFs) on these membranes, we compared the electroporation responses of the single and double membranes under the same field strength employing molecular dynamics (MD) simulations. Our results demonstrate that the double membrane underwent faster electroporation, attributed to inter-membrane counter-deformation under Coulomb force, which modulated the local electric field direction and reduced membrane tension. Compared to the single membrane, the double membrane may be more susceptible to damage induced by nsPEFs. This finding may provide a molecular-scale theoretical reference for understanding the electroporation mechanism of the nuclear envelope relative to the plasma membrane under nsPEFs.
The authors' abstract, as published at the source. PLoS ONE, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
BiotechnologyBiochemistry, Genetics and Molecular Biology