Eurosurveillance· 2026Q1
Fatal encephalitis caused by Shamonda virus Europe 1 (SHAV-EU1) in a patient with a severely weakened immune system, France, 2026
- 1citations
- Q1SCImago
- 2026year
Short summary
The first human infection with Shamonda virus Europe 1 (SHAV-EU1) caused fatal encephalitis in an immunocompromised patient in France, 2026.
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Key points
- First human infection with Shamonda virus Europe 1 (SHAV-EU1) reported in France, 2026.
- The patient had a severely weakened immune system due to allogeneic stem cell transplantation.
- Fatal encephalitis was diagnosed, with SHAV-EU1 detected in cerebrospinal fluid and CNS biopsies.
- The virus was present in serum, respiratory, and stool samples for over two months before encephalitis onset.
AI-generated from the title and abstract; the full text is not read.
Abstract
New Shamonda virus clades (SHAV-EU1 and SHAV-EU2) emerged in Europe in summer 2026, primarily affecting cattle. We report the first human infection with SHAV-EU1: a French patient with a severely weakened immune system developed fatal encephalitis in September 2026, 1 month after their allogeneic stem cell transplantation. Metatranscriptomics detected SHAV-EU1 in cerebrospinal fluid, confirmed by RT-PCR. Biopsies from central nervous system showed high viral loads. Investigations revealed SHAV-EU1 in serum, respiratory and stool samples at least for 2 months before encephalitis onset.
The authors' abstract, as published at the source. Eurosurveillance, 2026 · DOI ↗
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Field: Infectious Diseases
Infectious DiseasesMedicine