Journal of Oral and Maxillofacial Pathology· 2012Q3· Review
Toluidine blue: A review of its chemistry and clinical utility
- 452citations
- Q3SCImago
- 2012year
Short summary
Toluidine blue, a metachromatic dye, effectively stains acidic tissue components rich in DNA/RNA, proving useful for vital staining of oral dysplasia/carcinoma and special staining of mast cells, mucins, and cartilage.
AI-generated from the title and abstract; the full text is not read.
Key points
- Toluidine blue is a metachromatic dye with high affinity for acidic tissue components.
- It stains tissues rich in DNA and RNA.
- Used as a vital stain in vivo to identify oral dysplasia and carcinoma.
- Used as a special stain to highlight mast cells, mucins, and cartilage in tissue sections.
AI-generated from the title and abstract; the full text is not read.
Abstract
Toluidine blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components, thereby staining tissues rich in DNA and RNA. It has found wide applications both as vital staining in living tissues and as a special stain owing to its metachromatic property. Toluidine blue has been used in vivo to identify dysplasia and carcinoma of the oral cavity. Use of toluidine blue in tissue sections is done with the aim to highlight components, such as mast cells granules, mucins, and cartilage. This article provides an overview on chemistry, technique, and the various applications of toluidine blue.
The authors' abstract, as published at the source. Journal of Oral and Maxillofacial Pathology, 2012 · DOI ↗
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Field: Oral Surgery
Oral SurgeryDentistry