Journal of Alzheimer s Disease· 2026Q1
Neuroprotective potential of woohwangchungsimwon for dementia and mild cognitive impairment: Its key components, compounds, and bioactivities
- 0citations
- Q1SCImago
- 2026year
Short summary
Woohwangchungsimwon (WCW), a traditional multi-component herbal formulation, shows potential for treating dementia and mild cognitive impairment (MCI) by targeting multiple pathological processes.
AI-generated from the title and abstract; the full text is not read.
Key points
- Woohwangchungsimwon (WCW) is a traditional multi-component herbal formulation with historical use for neurological stability.
- Eight key components of WCW possess neuroprotective, anti-inflammatory, and antioxidant properties.
- WCW's multi-component nature suggests potential for targeting multiple pathological processes in dementia and MCI.
- Current evidence is primarily from preclinical studies and broader neurological contexts.
AI-generated from the title and abstract; the full text is not read.
Abstract
Dementia is a progressive neurodegenerative disorder characterized by cognitive decline that compromises daily functioning, with Alzheimer's disease (AD) representing its most prevalent form. Mild cognitive impairment (MCI) represents a prodromal stage of AD and provides an important window for early intervention. Woohwangchungsimwon (WCW) is a multicomponent natural medicinal formulation historically used to promote cardiovascular and neurological stability and to alleviate excessive heat and phlegm. This review evaluated the potential of WCW to ameliorate symptoms associated with dementia and MCI. A narrative review of experimental and pharmacological studies was conducted to examine the bioactive compounds, bioactivities, mechanisms, and reported outcomes of eight key natural medicinal components of WCW: Angelicae Gigantis Radix, Calculus Bovis, Cinnamomi Cortex, Dioscoreae Rhizoma, Ginseng Radix, Glycyrrhizae Radix, Hoelen and Zingiberis Rhizoma, which possess neuroprotective, anti-inflammatory and antioxidant activities. Although current evidence regarding WCW and its active components is derived predominantly from preclinical models and studies conducted within broader neurological contexts, its multicomponent nature suggests significant potential for targeting multiple pathological processes relevant to dementia and MCI. Well-designed clinical trials are now needed to clarify the therapeutic efficacy and safety of WCW in patients with cognitive impairment.
The authors' abstract, as published at the source. Journal of Alzheimer s Disease, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Complementary and alternative medicine
Complementary and alternative medicineMedicine