Journal of Agricultural and Food Chemistry· 2026Q1
Propionyl-Fructooligosaccharide Alleviates DSS-Induced Colitis in Association with Changes in Gut Microbiota, Inflammatory Responses, and Intestinal Barrier Function
- 0citations
- Q1SCImago
- 2026year
Short summary
Propionyl-fructooligosaccharide (P-FOS) significantly reduced disease activity, colon damage, and inflammation in a DSS-induced colitis mouse model.
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Key points
- P-FOS treatment reduced disease activity, colon shortening, and histological injury in DSS-induced colitis mice.
- P-FOS decreased expression of inflammation-associated markers and increased barrier-related gene/protein expression (e.g., Muc2 mRNA, occludin protein).
- P-FOS altered gut microbial diversity and composition, and colonic short-chain fatty acid profiles.
- The study did not confirm a colon-targeted release mechanism for P-FOS.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Propionyl-fructooligosaccharide (P-FOS), an esterified prebiotic synthesized from fructooligosaccharides and propionic acid, was evaluated in a dextran sulfate sodium (DSS)-induced colitis mouse model. P-FOS treatment was associated with lower disease activity, attenuated colon shortening, reduced histological injury, and the preservation of goblet cells. P-FOS also decreased the expression of several inflammation-associated markers and increased barrier-related gene and protein expression, including Muc2 mRNA and occludin protein. In addition, P-FOS treatment was associated with changes in gut microbial diversity and composition and with altered colonic short-chain fatty acid profiles. Because gastrointestinal stability, ester bond cleavage, and direct propionate release from P-FOS were not determined, these findings should not be interpreted as direct evidence of a colon-targeted release mechanism. Overall, P-FOS showed protective effects in DSS-induced colitis and warrants further investigation as an esterified prebiotic.
The authors' abstract, as published at the source. Journal of Agricultural and Food Chemistry, 2026 · DOI ↗
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Field: Nutrition and Dietetics
Nutrition and DieteticsNursing