Evaluation of Effects on Skin Quality of a Centella asiatica Extracellular Vesicle-based Skin Care Formulation: A 28-Day Facial Skin Quality Study

Abstract

Abstract Skin damage results from the natural aging process, physical damage, UV light, and environmental pollutants. Centella asiatica (Cica) is a traditional medicinal herb known to have therapeutic effects on skin and wound healing. This study aims to evaluate the effects of skincare formulation Kristen Claire Supreme Rejuvenation Essence with Cica EV as the main active ingredient, on facial appearance and skin quality in healthy participants. Twenty healthy participants (4 males and 16 females; average age 36.5) were enrolled and underwent a 24-hour skin patch test on the forearm to assess potential irritation or allergic reactions. The test product was applied twice daily for 28 days. Facial skin quality assessments were conducted before use and at 7, 14, 21, and 28 days of product application. Measured parameters included skin hydration, melanin content, skin elasticity, wrinkle percentage, redness area percentage, and pore percentage. After 28 days of test product treatment, significant improvements were observed in skin hydration and elasticity, wrinkle, redness, and pore distribution, while skin melanin content was reduced significantly. Kristen Claire Supreme Rejuvenation Essence effectively improved skin hydration, elasticity, and texture, and brightened the complexion, making it a promising candidate for skincare applications.

The authors' abstract, as published at the source. medRxiv, 2025 · DOI ↗