ACS Applied Nano Materials· 2026Q1
Advanced Cobalt Nanocatalyst on Covalently Functionalized Halloysite for Alkoxy- and Aminocarbonylations
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- 2026year
Short summary
A new cobalt nanoparticle catalyst supported on halloysite nanotubes functionalized with peralkylguanidine (CoNPs@HAL-PAG) achieves up to 80% yield in alkoxy- and aminocarbonylation of iodoarenes, outperforming non-functionalized catalysts.
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Key points
- Developed a CoNPs@HAL-PAG nanocatalyst using halloysite nanotubes functionalized with peralkylguanidine.
- The catalyst achieved high yields (up to 80%) in alkoxy- and aminocarbonylation of iodoarenes to esters and amides.
- CoNPs@HAL-PAG demonstrated improved performance compared to non-functionalized cobalt nanoparticle catalysts.
- The system showed broad substrate scope, successfully synthesizing the drug benzocaine.
- This represents an early example of a supported dual system using a strong proton acceptor and non-noble metal for these reactions.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Herein, we report the design of a bifunctional nanocatalyst comprising cobalt nanoparticles (CoNPs) and covalently functionalized halloysite nanotubes with peralkylguanidine moieties (HAL-PAG) for alkoxy- and aminocarbonylation processes mediated via dual catalysis. The nano-tubular morphology of naturally occurring halloysite, combined with peralkylguanidine functionalization, promotes efficient nanoparticle distribution on the support, avoiding agglomeration. A full characterization of the innovative nanomaterials confirms both the successful immobilization and the chemical environment of the CoNPs. Under optimized conditions, the CoNPs@HAL-PAG catalyst enables the alkoxy and amino-carbonylation of iodoarenes to the corresponding esters and amides, respectively, in high yields (up to 80%), significantly improved in comparison with the non-functionalized CoNPs@HAL catalytic material. CoNPs@HAL-PAG exhibits broad substrate scope across various aryl iodides, alcohols, and amines, including the synthesis of the blockbuster drug benzocaine. To the best of our knowledge, this represents one of the first examples of supported dual systems, encompassing both peralkylguanidine as a strong proton acceptor and non-noble metal-based nanoparticles applied to the alkoxy- and aminocarbonylations of aryl halides. This system offers a robust and recyclable catalyst for the sustainable synthesis of aryl esters and amides.
The authors' abstract, as published at the source. ACS Applied Nano Materials, 2026 · DOI ↗
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Process Chemistry and TechnologyChemical Engineering