Cellular and Molecular Immunology· 2026Q1· Review
Macrophage biology and immunoregulation in health and disease
- 0citations
- Q1SCImago
- 2026year
Short summary
Macrophages exhibit extensive diversity and adapt to local environments through ontogeny, sensing, metabolism, and epigenetics, influencing health and disease.
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Key points
- Macrophages are versatile immune cells that maintain tissue homeostasis and shape disease progression.
- Single-cell, spatial, and multiomics technologies have revealed extensive diversity in tissue-specific macrophage identities.
- Macrophage behavior emerges from the coordinated integration of ontogenetic imprinting, environmental sensing, metabolic rewiring, and epigenetic remodeling.
- These factors collectively determine macrophage responses in inflammatory diseases, neurodegeneration, and cancer.
- Insights into macrophage plasticity and function can inform next-generation therapeutic strategies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Macrophages are versatile immune cells that maintain tissue homeostasis and shape disease progression through continuous adaptation to the local environment. Recent advances in single-cell, spatial, and multiomics technologies have revealed extensive diversity in tissue-specific macrophage identities and their adaptation to physiological and pathological contexts. Emerging evidence indicates that macrophage behavior emerges from the coordinated integration of ontogenetic imprinting, environmental sensing, metabolic rewiring, and epigenetic remodeling. These interconnected layers collectively determine macrophage responses in inflammatory diseases, neurodegeneration, and cancer, creating both challenges and opportunities for therapeutic intervention. In this review, we provide an overview of recent mechanistic insights into the molecular circuits governing macrophage plasticity and function and discuss how this evolving framework can inform next-generation macrophage-based therapeutic strategies to restore immune homeostasis and improve disease outcomes.
The authors' abstract, as published at the source. Cellular and Molecular Immunology, 2026 · DOI ↗
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ImmunologyImmunology and Microbiology