Amino Acids· 2026Q1
Renal effects of chronic D-serine administration in a Parkinson’s disease rat model: evidence for a threshold nephrotoxic dose
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- Q1SCImago
- 2026year
Short summary
A chronic daily dose of 200 mg/kg D-serine in rats induced kidney inflammation and altered growth/water consumption, similar to acute toxic effects, suggesting this is a threshold dose for prolonged administration.
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Key points
- Chronic daily D-serine (200 mg/kg) for 8 weeks caused kidney inflammation in rats.
- Biological alterations, including growth and water consumption, were observed.
- The observed effects were comparable to acute D-serine nephrotoxicity.
- 200 mg/kg is suggested as a threshold dose for chronic D-serine administration in rats.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract D-serine, an endogenous co-agonist at the glycine binding site of NMDA receptor GluN1 subunits, is increasingly studied in Parkinson’s disease, where altered levels have been detected in both patients and animal models. Using a rat model based on α-synuclein overexpression, we evaluated renal effects after eight weeks of daily D-serine administration, alone or in combination with L-DOPA. Given the known acute nephrotoxicity of D-serine in rats, this study addresses the lack of data on chronic exposure. Our results show that a dose of 200 mg/kg induces biological alterations - reflected in growth patterns and water consumption - and peritubular inflammatory infiltrates comparable to the nephrotoxic effect reported after acute treatment. These findings suggest that 200 mg/kg could represent a threshold dose for chronic D-serine administration in rats, providing a useful reference for future studies involving prolonged treatment.
The authors' abstract, as published at the source. Amino Acids, 2026 · DOI ↗
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Field: Neurology (Medicine)
Clinical NeurologyMedicine