Pharmaceutical Biology· 2025
Moringa Tohumu Bileşikleri, Metabolizmayı Yeniden Programlayarak Diyabetik Böbrek Hastalığıyla Savaşır
Cyanoglycosides isolated from Moringa oleifera seeds inhibited PFKFB3/TGF-β1/smads pathway to alleviate diabetic nephropathy through driving metabolic reprogramming
- 52atıf
- 2025yıl
Kısa özet
Moringa oleifera tohumlarından izole edilen iki yeni siyanoglikozit ve üç bilinen bileşik, PFKFB3/TGF-β1/Smads yolunu inhibe ederek ve hücresel metabolizmayı yeniden programlayarak böbrek hücrelerini yüksek glukoz hasarından korudu.
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Ana noktalar
- Moringa oleifera tohumlarından iki yeni siyanoglikozit ve üç bilinen bileşik izole edildi.
- Beş bileşik de yüksek glukoz kaynaklı böbrek hücresi modelinde böbreği koruyucu etkiler gösterdi.
- Koruyucu mekanizma, oksidatif stresi, inflamasyonu baskılamayı ve TGF-β1/Smad yolunu inhibe etmeyi içerir.
- Bileşikler PFKFB3 ekspresyonunu modüle etti ve metabolik yeniden programlamayı teşvik etti.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Context Diabetic nephropathy (DN) is a major complication of diabetes. Moringa oleifera seeds are recognized as a source of bioactive compounds with potential health benefits, prompting investigation into their specific components and effects on DN.Objective This study aimed to isolate bioactive compounds from M. oleifera seeds and evaluate their renoprotective effects and underlying mechanisms of action against high-glucose-induced diabetic nephropathy.Materials and methods Four cyanoglycosides and one cyanoaglycone were isolated from M. oleifera seeds using chromatographic techniques. The renoprotective effects of these compounds were then evaluated using an in vitro model of high-glucose-induced diabetic nephropathy in HBZY-1 mesangial cells. Mechanistic studies further investigated the compounds’ effects on oxidative stress, inflammation, mitochondrial function, expression of the glycolysis-related protein PFKFB3, and the TGF-β1/Smad signaling pathway.Results Two previously undescribed cyanoglycosides were isolated alongside three known compounds. All five compounds demonstrated significant renoprotective effects in the high-glucose-induced HBZY-1 cell model. Mechanistically, these effects were achieved by suppressing oxidative stress and inflammation, protecting mitochondrial function, modulating the expression of the glycolysis-related protein PFKFB3, and inhibiting the TGF-β1/Smad signaling pathway, collectively contributing to beneficial metabolic reprogramming.Conclusions This study isolated two novel cyanoglycosides from M. oleifera seeds. These compounds, alongside known ones, protect against high-glucose-induced renal injury. Their renoprotection involves metabolic reprogramming via suppressing oxidative stress/inflammation, preserving mitochondrial function, modulating PFKFB3, and inhibiting TGF-β1/Smad signaling. These findings offer insights for utilizing M. oleifera seeds and suggest these cyanoglycosides as potential diabetic nephropathy therapeutics.
Yazarların özeti; kaynağından alınmıştır. Pharmaceutical Biology, 2025 · DOI ↗
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Plant ScienceAgricultural and Biological Sciences