PLoS Biology· 2026Q1
Therapeutic delivery systems need to focus on cellular precision to target neurodegeneration
- 1citations
- Q1SCImago
- 2026year
Short summary
Future brain drug delivery systems must prioritize precise targeting of specific cells within affected brain regions, rather than just crossing the blood-brain barrier, to effectively combat neurodegeneration.
AI-generated from the title and abstract; the full text is not read.
Key points
- The main hurdle for brain drug delivery is cellular and regional specificity, not blood-brain barrier penetration.
- Effective treatment of neurodegeneration requires targeting specific cells within affected brain areas.
- The dynamic nature of the neurovascular unit adds complexity to therapeutic delivery.
- Current delivery systems need to evolve beyond barrier crossing to achieve cellular precision.
AI-generated from the title and abstract; the full text is not read.
Abstract
The central problem when delivering drugs to the brain is no longer crossing the blood-brain barrier, but delivering therapeutics to the right cells, in the right regions to target neurodegeneration, within a dynamically changing neurovascular unit.
The authors' abstract, as published at the source. PLoS Biology, 2026 · DOI ↗
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Field: Biomaterials
BiomaterialsMaterials Science