Annals of the New York Academy of Sciences· 2026Q1
Levodopa and Subthalamic Nucleus Deep Brain Stimulation Modulate Excitation/Inhibition Balance and the Neural Encoding of Isochronous Sequences in Persons With Parkinson's Disease
- 1citations
- Q1SCImago
- 2026year
Short summary
Levodopa and subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease patients alter the brain's excitation/inhibition (E/I) balance and improve the neural encoding of rhythmic auditory sequences.
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Key points
- Levodopa and STN DBS alter beta-band neural responses to isochronous auditory sequences in Parkinson's patients.
- Both treatments improve the brain's ability to track rhythmic auditory stimuli, as shown by increased delta-band inter-trial phase coherence.
- The excitation/inhibition (E/I) balance in the brain is modulated by levodopa and STN DBS.
- Changes in E/I balance correlated with improvements in motor symptom severity (UPDRS-III) following levodopa administration.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Temporally regular auditory stimuli, as found in isochronous sound streams, metronome beats, or music, are often used in rhythmic auditory stimulation (RAS) interventions to initiate and stabilize the temporal coordination of motor plans in persons with Parkinson's disease (pwPD). Research suggests that RAS promotes the recruitment of a cerebellar‐prefrontal network and recalibrates abnormal β‐band synchronization in the striato–thalamo–cortical pathway. These cuing effects can resemble those observed via dopaminergic treatments (e.g., levodopa) and deep brain stimulation (DBS) targeting the subthalamic nucleus (STN). Here, we investigated the influence of both levodopa administration and STN DBS on the neural encoding of isochronous auditory sequences in pwPD. A comprehensive analysis of electroencephalography (EEG) data revealed changes in β‐band event‐locked neural responses, as well as event‐related potentials, neural tracking of rhythm (δ‐band inter‐trial phase coherence), and excitation/inhibition balance (E/I) as a function of these treatments. Furthermore, we characterized the link between changes in E/I and motor symptom severity (UPDRS‐III) with levodopa administration. We suggest that characterizing individual responses to specific treatments is a fundamental step in tailoring rehabilitation protocols and optimizing intervention efficacy.
The authors' abstract, as published at the source. Annals of the New York Academy of Sciences, 2026 · DOI ↗
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Field: Neurology (Medicine)
NeurologyMedicine