ACS Biomaterials Science & Engineering· 2026Q1· Review
Polymeric Biomaterials with Multiple Stratified Layers for Periodontal Ligament/Bone Regeneration: A Review
- 0citations
- Q1SCImago
- 2026year
Short summary
Multilayer biomaterials show promise for periodontal ligament and bone regeneration, but current designs struggle to replicate native tissue structure and achieve adequate mechanical stability and osseointegration.
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Key points
- Periodontitis causes progressive destruction of tooth-supporting tissues, leading to tooth loss.
- Current GTR/GBR biomaterials lack adequate mechanical stability and osseointegration.
- Multilayer biomaterials are being developed to overcome these limitations.
- Existing multilayer designs struggle with structural incompatibilities between layers, hindering full replication of native periodontal tissues.
AI-generated from the title and abstract; the full text is not read.
Abstract
Periodontitis is a chronic pathological condition initiated by bacterial plaque accumulation and characterized by the progressive destruction of the tooth-supporting tissues, including the periodontal ligament, cementum, and alveolar bone. If left untreated, it may result in tooth mobility, pathologic tooth migration, and ultimately tooth loss. Despite numerous regenerative strategies, complete periodontal regeneration remains challenging. Guided tissue regeneration (GTR) and guided bone regeneration (GBR) promote the regeneration of the periodontal ligament and alveolar bone; however, current GTR/GBR biomaterials often exhibit inadequate mechanical stability and osseointegration. To overcome these limitations, various multilayer biomaterials with enhanced functionalities have been developed. This review outlines the key properties required for GTR/GBR, evaluates the design and performance of current multilayer biomaterials, and examines their major limitations, particularly their inability to fully replicate native periodontal tissues due to structural incompatibilities between layers. Finally, future directions and recommendations are presented to guide the development of next-generation GTR/GBR biomaterials.
The authors' abstract, as published at the source. ACS Biomaterials Science & Engineering, 2026 · DOI ↗
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Field: Urology
UrologyMedicine