Trends in biotechnology· 2026Q1· Review
Toward industrial microalgae-based monoclonal antibody production
- 0citations
- Q1SCImago
- 2026year
Short summary
Microalgae offer a scalable, low-cost alternative to traditional Chinese hamster ovary (CHO) cells for monoclonal antibody (mAb) production, potentially enabling new markets beyond therapeutics.
AI-generated from the title and abstract; the full text is not read.
Key points
- Microalgae offer light-driven growth and low-cost media for mAb production.
- Microalgal systems provide potential for significant and efficient scalability.
- Reduced production costs could enable novel market opportunities for mAbs.
- This approach contrasts with current CHO cell systems, which have high operational and capital costs.
AI-generated from the title and abstract; the full text is not read.
Abstract
Over the past two decades, Chinese hamster ovary cells have dominated monoclonal antibody (mAb) production. Although this mammalian cell system carries high operational and capital costs, it aligns well with regulatory requirements for producing high-value, modest-scale therapeutics. However, microalgal systems offer the benefits of light-driven growth, low-cost media, and the potential for significant and efficient scalability, providing a promising route for producing lower-cost mAbs. Reducted production costs and increased scale open novel market opportunities well beyond the therapeutic space. Here, we investigate the history of mAb production in microalgae, the recent molecular and bioprocessing advances that are likely to contribute to their industrial production, and the novel applications that could arise given access to lower-cost mAbs.
The authors' abstract, as published at the source. Trends in biotechnology, 2026 · DOI ↗
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BiotechnologyBiochemistry, Genetics and Molecular Biology