INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY· 2026Q2
Description of Corynebacterium nasorum sp. nov. and Corynebacterium hallucis sp. nov. isolated from human nasal passages and skin
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- Q2SCImago
- 2026year
Short summary
Two novel Corynebacterium species, C. hallux and C. nasorum, were identified from human nasal and skin samples, distinguished by genomic analysis showing <95% average nucleotide identity to known species.
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Key points
- Two novel Corynebacterium species, C. hallux and C. nasorum, were isolated from human nasal and skin samples.
- Both species require oleic acid for growth and share major fatty acids: 18:1 ω9c, 16:0, and 18:0.
- Genomic analysis, including 16S rRNA gene sequencing and whole-genome sequencing, confirmed their status as distinct species.
- These new species showed less than 95% average nucleotide identity to their closest known relative, C. tuberculostearicum.
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Abstract
Abstract Strains of two novel Corynebacterium species were cultured from samples of human nostrils and skin collected in the United States and Botswana. These strains demonstrated growth on Columbia Colistin-Nalidixic Acid agar with 5% sheep blood and in liquid media (brain heart infusion and tryptic soy broth) supplemented with Tween 80, a source of the fatty acid oleic acid. Cells were Gram-positive, non-spore-forming, non-motile bacilli that showed catalase but not oxidase activity. Major fatty acids in both of these species were 18:1 ω9c (oleic acid), 16:0 (palmitic acid), and 18:0 (stearic acid). Analysis of the 16S ribosomal RNA gene sequences identified these strains as belonging to the genus Corynebacterium (family Corynebacteriaceae). Whole-genome sequencing revealed that these strains formed distinct branches on a phylogenomic tree, with C. tuberculostearicum being the closest relative but with average nucleotide identities of < 95% relative to all previously described species. These results indicate that these strains represent novel species of Corynebacterium , for which we propose the names Corynebacterium hallux sp. nov., with the type strain CTNIH22 T (=ATCC TSD-435 T =DSM 117774 T ), and Corynebacterium nasorum sp. nov., with the type strain KPL3804 T (=ATCC TSD-439 T =DSM 117767 T ). We also describe the characteristics of two strains isolated from human nasal passages that are members of the recently named species Corynebacterium yonathiae . Repositories The sequencing files supporting the conclusions of this study are available in the Sequence Read Archive (PRJNA804245, PRJNA854648, PRJNA842433). The partial 16S ribosomal RNA gene sequences from PCR amplification and Sanger sequencing are available in GenBank for Corynebacterium hallux sp. nov. CTNIH22 T (accession number: PQ252679 ) and Corynebacterium nasorum sp. nov. KPL3804 T (accession number: PQ149068 ) . The annotated genomic sequences for the strains characterized in this study have been deposited in GenBank with the following accession numbers: C. hallux sp. nov. CTNIH22 T (GCF_032821755.1), C. nasorum sp. nov. KPL3804 T (GCF_037908315.1), C. nasorum sp. nov. MSK185 (GCF_030229765.1), C. yonathiae KPL2619 (GCF_037908465.1), and C. yonathiae MSK136 (GCF_022288805.2).
The authors' abstract, as published at the source. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2026 · DOI ↗
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EndocrinologyBiochemistry, Genetics and Molecular Biology