BioChem· 2026Q2
Ipomoea aquatica Extracts Attenuate Streptozotocin-Diabetes-Induced Alterations of Liver, Oxidative Stress, and Cancer Cell Lines in Rats
- 2citations
- Q2SCImago
- 2026year
Short summary
Two fractions of Ipomoea aquatica (IA6-1 and IA9-2) significantly increased liver total antioxidant capacity (TAC) in diabetic rats and reduced the intensity of C-reactive protein and apelin, suggesting a protective effect against oxidative stress and inflammation.
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Key points
- Ipomoea aquatica fractions (IA6-1, IA9-2) increased liver total antioxidant capacity (TAC) in STZ-induced diabetic rats.
- Both fractions reduced the intensity of C-reactive protein (28.3 kDa) and apelin (16 kDa) in diabetic rat plasma.
- The IA6-1 fraction showed a more potent antiproliferative effect on liver cancer HepG2 cell lines in vitro.
- Serum ALP and AST levels were significantly increased in treated groups, while ALT, total protein, and albumin showed no significant differences compared to control.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract This study aimed to investigate the potential ameliorative and antihyperglycemic effects of two fractions ofIpomoea aquaticaon liver functions in streptozotocin (STZ)-induced diabetic male rats. Eighteen adult male albino rats were divided into three groups: control,STZ + 200 mg/kgIA6-1(dichloromethane-ethyl acetate fraction), andSTZ + 200 mg/kgIA9-2(ethyl acetate-methanol fraction).In vitro, antiproliferative activity against liver cancer cell lines (HepG2) was examined. Additionally, the plasma protein profile ofSTZ-induced diabetic rats was investigated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Results showed a significant increase in serum alkaline phosphatase (ALP) and aspartate aminotransaminase (AST) in both treated groups compared to the control, whereas there was no significant difference between groups in the serum levels of alanine aminotransaminase (ALT), total protein, and albumin. Thein vivototal antioxidant capacity (TAC) showed a significant increase in both treated groups compared to the control, indicating thatI. aquaticamay enhance the antioxidant defense system of the liver, which could help protect the liver from oxidative stress-induced damage. The profile of C-reactive protein (C-RP) (28.3 kDa) and apelin (16 kDa) inSTZrats showed a higher intensity compared to the control group and both treated groups. These proteins may play a role in regulating inflammation and oxidative stress in the liver, which are important mechanisms in the pathogenesis of liver diseases. Moreover, theIA6-1fraction had a more potent antiproliferative effect on liver cancer HepG2cell lines compared to theIA9-2fraction. This suggests that the plant may have a protective effect against liver damage caused by cancer cells. Overall, these findings highlight the potential therapeutic applications ofI. aquaticafor the treatment of liver diseases, particularly those associated with oxidative stress and inflammation. However, further research is needed to fully elucidate the mechanisms underlying the plant's beneficial effects on liver function and to determine optimal dosages and treatment durations for humans. Additionally, clinical trials will be necessary to confirm the safety and efficacy ofI. aquaticaas a therapeutic agent for liver diseases in humans.
The authors' abstract, as published at the source. BioChem, 2026 · DOI ↗
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Field: Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and MetabolismMedicine