Chemosensors· 2026Q2
Analytical Performance Evaluation of the QuEChERS-GC-MS Method for the Analysis of Dieldrin in Fillets of Nile Tilapia Oreochromis niloticus
- 0citations
- Q2SCImago
- 2026year
Short summary
A new QuEChERS-GC-MS method accurately quantifies the probable human carcinogen dieldrin in Nile tilapia fillets, achieving a coefficient of determination (R2) of 0.9918 and a limit of quantification (LOQ) of 50 μg L−1.
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Key points
- Developed and validated a QuEChERS-GC-MS method for dieldrin analysis in Nile tilapia.
- Matrix-matched calibration corrected for a -21.17% signal suppression due to matrix effects.
- The method achieved good linearity with R2 = 0.9918.
- The reliable linear working range is above the LOQ of 50 μg L−1.
AI-generated from the title and abstract; the full text is not read.
Abstract
Organochlorine pesticide (OCP) residues act as critical drivers of environmental impacts and pose significant risks to human and animal health. This scenario is further exacerbated by their high environmental persistence, marked bioaccumulative potential, and chronic toxicity. The International Agency for Research on Cancer (IARC) classifies dieldrin, as well as aldrin when metabolized into this substance, as probably carcinogenic to humans (Group 2A). OCPs can accumulate in the fatty tissue of fish. Therefore, when consumed, fish can become a route of human exposure to OCPs, such as dieldrin. A novel method for determining dieldrin in Fillets of Nile tilapia (Oreochromis niloticus) using GC/MS and the original QuEChERS was developed and validated. The optimization of chromatographic parameters resulted in an appropriate retention time (Rt) for dieldrin. Matrix-matched calibration was established to correct the matrix effect (ME) in the quantitative analysis of the pesticide. Dieldrin showed matrix-induced signal suppression of -21.17%. The pesticide studied showed good linearity with a coefficient of determination (R2) of 0.9918. According to the analytical validation standards established by ANVISA, concentrations above the LOQ (50 μg L−1) can be used as a linear working range with high reliability.
The authors' abstract, as published at the source. Chemosensors, 2026 · DOI ↗
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Field: Food Science
Food ScienceAgricultural and Biological Sciences