Nature Methods· 2026Q1
Continuous mass photometry by single-molecule trapping
- 2citations
- Q1SCImago
- 2026year
Short summary
Continuous mass photometry enables hour-long, mass-resolved observation of individual biomolecules and their interactions with sub-kilodalton precision and millisecond resolution.
AI-generated from the title and abstract; the full text is not read.
Key points
- Introduces continuous mass photometry for single-molecule observation.
- Enables hour-long observation of biomolecules and their complexes.
- Achieves sub-kilodalton mass precision and millisecond temporal resolution.
- Uses supported lipid bilayers for molecular tethering.
AI-generated from the title and abstract; the full text is not read.
Abstract
The dynamic choreography of biomolecular interactions underpins the processes of life, but its direct observation remains challenging. Here we introduce continuous mass photometry, enabling hour-long, mass-resolved observation of individual biomolecules tethered to supported lipid bilayers, their complexes and interactions, with up to sub-kilodalton mass precision and millisecond temporal resolution. Our approach represents a quantitative time-resolved single-molecule measurement modality for studying complex biomolecular mechanisms in action.
The authors' abstract, as published at the source. Nature Methods, 2026 · DOI ↗
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BiophysicsBiochemistry, Genetics and Molecular Biology