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Immunity Inflammation and Disease· 2025Q2· Review

The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target

Shuyu Yang, Xi Yang

Short summary

Excessive reactive oxygen species (ROS) drive periodontitis progression by disrupting cellular balance and mediating inflammatory pathways like NF-κB and MAPK. Targeting the NLRP3 inflammasome with antioxidant and ROS-modulating therapies shows promise for mitigating inflammation and tissue degradation.

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PeriodonticsDentistry