International Journal of Molecular Sciences· 2025Q1· Review

Chronic Stress and Autoimmunity: The Role of HPA Axis and Cortisol Dysregulation

Sergio Gutierrez Nunez, Sara Peixoto Rabelo, Nikola Subotic, James P. Caruso et al.

92citations
Q1SCImago
2025year

Short summary

Chronic stress dysregulates the HPA axis and cortisol signaling, leading to impaired immune tolerance and fostering a pro-inflammatory state that promotes autoimmunity.

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Field: Behavioral Neuroscience

Behavioral NeuroscienceNeuroscience