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Frontiers in Immunology· 2025Q1· Review

Gut microbiota–derived metabolites in immunomodulation and gastrointestinal cancer immunotherapy

Wenbin Luo, Ruoyun Li, Chaofan Pan, Changjiang Luo

Short summary

Gut microbiota metabolites like SCFAs, bile acids, and tryptophan derivatives modulate immune cells and the tumor microenvironment, influencing GI cancer immunotherapy outcomes.

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