Nature Communications· 2026Q1

End processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis

Alex Vogt, Andrea M. Kaminski, Jason Williams, Tasmin Naila et al.

3citations
Q1SCImago
2026year

Short summary

Cryo-EM reveals that the DNA repair factors Pol λ and PNKP simultaneously bind to a short-range synaptic complex, coordinating end-processing for non-homologous end joining (NHEJ) of DNA double-strand breaks.

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Molecular BiologyBiochemistry, Genetics and Molecular Biology