Nature Communications· 2026Q1

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Kookjoo Kim, Huan Li, Yuan Qi, Zephan Melville et al.

3citations
Q1SCImago
2026year

Short summary

The RY12 domain of RyR1 acts as an ADP sensor and is the binding site for the malignant hyperthermia therapeutic dantrolene, which allosterically closes the receptor pore.

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Molecular BiologyBiochemistry, Genetics and Molecular Biology