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Scientific Reports· 2026Q1

The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets

Gerald Yu Liao, Jenna Klug, Swastik Singh, Elizabeth Bae et al.

Short summary

Intermittent dosing of rapamycin, acarbose, and phenylbutyrate starting at mid-life in house crickets (Acheta domesticus) extended lifespan and improved cognitive and motor functions, with rapamycin showing the most significant benefits.

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