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Journal of Magnetic Resonance Imaging· 2026Q1

MRI Proton Density Fat Fraction as a Biomarker of Marrow Recovery Following Organ‐Sparing Total Marrow Irradiation in Sickle Cell Disease

Malakeh Malekzadeh, Hemendra Ghimire, Ji Eun Lim, Srideshikan S. Madabushi et al.

Short summary

MRI-derived proton density fat fraction (PDFF) shows partial restoration of marrow fat in sickle cell disease (SCD) mice after organ-sparing total marrow irradiation (OS-TMI/BMT) and demonstrates initial feasibility in human patients.

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Field: Genetics

GeneticsMedicine